Hematopoietic Stem Cells

Shown are organs of a host that received a stem cell clone isolated from a GFP-transgenic mouse 7 months earlier. Donor type cells are green (GFP). The extend of repopulation seen in these organs exemplifies the tremendous proliferation and differentiation capacity of HSC.

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Genetic and Epigenetic Regulation of Hematopoietic Stem Cells

The behavior of hematopoietic stem cells (HSC) is governed by both extrinsic (environmental) and intrinsic mechanisms. HSC intrinsic mechanism include a strong genetic component that controls the size of the HSC compartment and the behavior of HSC in aging. Epigenetic mechanism were discovered in a clonal analysis of HSC. This revealed that the HSC compartment is comprised of a heterogeneous population of HSC with distinct developmental potential. Epigenetic regulation of stem cell lineage commitment and self-renewal: Linage-biased Stem cells detected in clonal analysis. Genes that control the size of the stem cell compartment Aging of hematopoietic stem cells Markers For Hematopoietic Stem Cells
The Power of a Hematopoietic Stem Cell. Shown are organs of a host that received a stem cell clone isolated from a GFP-transgenic mouse 7 months earlier. Donor type cells are green (GFP). The extend of repopulation seen in these organs exemplify the tremendous proliferation and differentiation capacity of a HSC.

Hematopoietic Stem Cells

Lineage-biased Stem Cells Detected in Clonal Analysis

Aging of Hematopoietic Stem Cells

Markers for Hematopoietic Stem Cells

Genes that Control the Size of the Stem Cell Compartment